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The latest news and blog posts from the World Nano Foundation.

Jack Hare 3/18/21 Jack Hare 3/18/21

Nanotech-powered £1 a day testing strategy can accelerate global recovery from pandemic

The rapid mass testing strategy costing just £1 a day per child can get children back to school and economies up and running, according to experts.

That is the small price of the rapid mass testing across schools in the UK, which is also hard on the heels of one of the world’s swiftest and most successful vaccination programmes.

A double whammy of rapid testing and vaccine deployment applied internationally could lead to a reduction of the human and economic hardship caused by much-criticised lockdown strategies, as well as the continued failure of ‘Track and Trace,’ which has swallowed up £32 billion in the UK.

The UK Government’s investment in vaccines started early, but its equally far-sighted adoption of inexpensive lateral flow test (LFT) kits is less well known.

The economical LFT utilizes nanoparticles to detect virus fragments in a test sample, identifying whether a subject is SARS-CoV-2 asymptomatic within 30 minutes. An individual can immediately isolate after a positive test, preventing transmission of COVID-19 at a rapid pace.

Some early scepticism about the devices has since been overwhelmed by new data and a robust rebuttal from Dr Susan Hopkins, COVID-19 Strategic Response Director to Public Health England, who said:

“Up to one in three people who have coronavirus never show any symptoms (asymptomatic) but that does not mean they are not infectious. Using LFTs enables us to rapidly identify people in the population who are asymptomatic, with results produced in 30 minutes.

“Lateral flow devices are effective at finding people with high viral loads who are most infectious and most likely to transmit the virus to others.”

And she added that the latest data suggested LFTs “are at least 99.9% specific which means that the risk of false positives is extremely low – less than one in a thousand.”

UK Government-sponsored LFT use in workplaces is already widespread, with nearly 50,000 UK businesses already registered for free kits, so that employees can be tested at least twice a week with fast results, enabling them to return to work and their children to get back into the classroom.

Each pupil must take two tests (£3.50 each) a week to show whether they need to be taken out of class to avoid infecting others and the same approach will be used for parents in the workplace.

“That’s remarkable value-for-money. £1 a day for an ‘insurance policy’ to enable schools to open, mums and dads to properly return to work, and the country to accelerate out of lockdown with the re-opening of hospitality and major venues no longer a distant prospect,” said Paul Sheedy, Co-founder of the not-for-profit World Nano Foundation (WNF) that promotes healthcare innovation and believes mass testing kits using nanotechnology are central to future pandemic protection.

Sheedy himself has co-developed Test2Suppress™ modelling to highlight how an LFT ‘Test to Suppress’ campaign allows early detection and immediate isolation, reducing the need for lockdowns.

He added: “The Government is rightly cautious about ending lockdown too early, so its medical advisors will pore over the data to check that the return to school and all workplaces maintain the falling infection rate.”

The next major battle will be the full re-opening of hospitality and major sporting and entertainment venues.

Britain’s Culture Secretary Oliver Dowden has announced plans for 20,000 fans to watch the FA Cup Final on May 15 and for a dozen other events, including the World Snooker Championships starting on April 17, to go ahead providing spectators return a negative LFT and can be tested again afterwards. This means they will not need to comply with social distancing at the event.

This level of social interaction will finalise ‘Operation Moonshot’ – the Johnson Government’s use of targeted mass testing to halt and drive back COVID-19.

Daniel Elliott, CEO of Innova Medical Group – the world's biggest supplier of COVID-19 LFT kits – confirmed that the UK government was his biggest customer, with a billionth kit about to be delivered and the company looking to open a UK production site to meet demand.

Innova is also in discussions with UK pharmacy chains to sell direct to consumers and Elliott added: "A mass testing strategy is most protective in businesses like personal care, pubs, clubs and a lot of events, where close contact in enclosed spaces can't be avoided."

Jack Hare 2/9/21 Jack Hare 2/9/21

UK GOVERNMENT AND SCIENTIFIC EXPERTS GET BEHIND COMMUNITY RAPID MASS TESTING

Following on from UK Prime Minister Boris Johnson’s quoted £7bn mass testing “Moonshot” programme where the government are deploying over £1.2bn’s worth of rapid lateral flow antigen tests to identify asymptomatic cases in communities and workplaces.

In what many believe was a game changer in preventing lockdowns across the world, in the UK, community and workplace lateral flow rapid test kits (LFTs) have been mobilised now for door-to-door delivery – the UK government has secured more than 400 million of these kits – for its “Test to Suppress” strategy as well as to address fears that the South African variant had broken out in areas of the country.

The World Nano Foundation and scientific leaders say regular use of inexpensive mass lateral flow rapid antigen test kits is the way to beat COVID-19, its variants, and future viruses. Governments and politicians are now reducing the spread of the virus and ensuring a quicker return to normality for their electorate and themselves by adopting a mass testing approach to pinpoint hotspots, thus targeting areas, and preventing wide scale restrictions.

As vaccination quickens for vulnerable members of society, the next prize is to get the world’s economies moving, with mass frequent testing as the key, using the mantra ‘test to suppress’, and as an early warning system to protect against new strains and future outbreaks. By using mass rapid testing, it can be identified where there are infectious cases and ensure that the virus is not passed on, breaking chains of transmission and allowing non-infected communities to continue without disruption.

These simple-to-manufacture rapid tests have shown a thousand-fold increase in the effectiveness and accuracy of testing with this technology. The kits can produce a positive result even when there are fewer antigens to the virus in the sample – vital for finding asymptomatic individuals and ‘super-spreaders’.

Many other countries and industries are now adopting this technology.

This week, The Biden administration announced the investment of $230 million in at-home coronavirus testing kits, to identify cases of the virus across the country to break chains of transmission and prevent new strains from disrupting communities and workplaces.

Innova Medical – the world's largest manufacturer of rapid lateral flow antigen tests is ramping up to 50 million a day by the spring – has also confirmed that its COVID-19 product is effective in detecting variant strains such as the British (Kent), South African, and Brazilian variants, which appear more contagious than the earlier strains.

"As these dangerous strains show signs of increased transmissibility across communities, the global effort to eliminate COVID-19 requires frequent, comprehensive and equitable testing that can detect these emerging strains," said Daniel Elliott, President and CEO of Innova Medical Group.

Elliot added that numerous studies have shown that rapid antigen tests are an important tool for identifying infectious people quickly and equitably, even when they may not have COVID-19 symptoms, in ways not possible with slower, more expensive, centralised lab-based tests.

He said the virus continues to morph its genetic ribonucleic acid (RNA) to generate new and potentially more contagious variants, but Innova's antigen test is effective because it looks for multiple proteins in the virus.

Workplace and community rapid mass testing is already starting to take place to keep economies moving and the entertainment and sports industries are said to be looking at a ‘day pass’ testing approach using LFT kits, in the same way that temperature checks were made on people using restaurants and pubs between lockdowns.

A trial is already under way in France using a music theatre to give day pass security so that people can start attending mass events again.

World Health Organisation Special Envoy on COVID-19, David Nabarro, had already suggested this approach:

"We’ve seen it (rapid mass testing) used in many different locations, for example in trying to keep aircraft free of people who’ve got COVID or looking after major events.”

A UK Government initiative offering LFTs in workplaces - healthcare, education, and local authorities, with private companies such as Royal Mail, the DVLA and Tate & Lyle Sugars also adopting frequent rapid testing.

Globally renowned British doctors’ journal, The Lancet, backed this approach after publishing an exhaustive study of quarantine and testing measures, and leading UK scientists and clinical experts have added their weight.

Oxford University researchers found the UK Government's most sensitive LFTs detected 83-90% of all infectious cases of COVID-19 and, with the UK investing more than £1.5bn in these test kits so far.

Oxford’s Regius Professor of Medicine, Sir John Bell underlined the benefit of these tests removing infectious people from high-risk environments: “They’ve found 25,000 cases just in healthcare, which may have prevented tens of thousands of cases of the disease.”

Tim Peto, Professor of Medicine, Infectious Disease, Nuffield Department of Clinical Medicine, Oxford University addressed the contrasts between PCR (polymerase chain reaction) swab testing and lateral flow kits:

“PCR is very good at telling you’ve had the virus or got the virus, but it doesn’t tell you whether you are infectious or not and the other problem about the swab test is that it takes a day or two…to get the answer back. The LFT has the enormous advantage of giving you an answer in about 30 minutes.”

He said this allows immediate self-isolation and individuals can also quickly advise their contacts so, “within a few hours, a local outbreak can be detected. This can’t be done with the swab (PCR) tests” adding that LFTs “detect people with high viral loads…the very people who are infectious.”

The World Nano Foundation (WNF) promotes healthcare technology and predicts that mass testing is central to future pandemic protection.

The not-for-profit organisation’s Co-founder Paul Sheedy said: “Our research shows how healthcare diagnostics technology will shift dramatically to a more decentralised community early intervention model, against potential epidemics and pandemics.

“The Test2Suppress™ campaign shows that intensive front-line initiatives using rapid test kits available to the individual will allow early detection and immediate isolation, reducing the need for lockdowns.

“And our simulation maps how consecutive daily tests for three days can rapidly identify and isolate infectious people. Weekly testing can then sustain a low infection rate even in a large population.

“A key point previously missed by some experts is that high quality rapid lateral flow tests are not for people who already think they have COVID-19; it’s about everyone else testing frequently to check they are not infectious.

“Used alongside vaccines and other preventative methods, these simple tests have been developed from colloidal gold nanoparticle research and are a vital component in the battle to defeat the virus and it’s future variants.

“Rapid community testing is simpler, faster, cheaper, more effective and mobilises everyone to help themselves, their relatives, friends, and colleagues, to keep everyone safe.

“With the work that we do, we know that there are even more exciting technologies on the way that will be central to the world’s fight for pandemic protection and future healthcare.

“We have already seen the danger from not being on our guard against renewed viral threats. Spanish Flu struck in 1918, killing up to 50 million people in four waves, the last two being most deadly because public health warnings were not adhered to.”

This means that there will be a revolution in healthcare in the coming years. Healthcare investment is forecast to grow at a rate of nearly 50% a year towards a market set to be worth $1.333 trillion by 2027*. The acceleration highlights wide recognition that the world cannot afford the human and economic cost of another pandemic.

One international investment platform is a Pandemic Protection alternative investment fund operated by Vector Innovation Fund in Luxembourg focused on limiting the effect of long form Covid-19, insulating the world against the impact of future pandemics, whilst minimising any impact on the global economy and healthcare provision and preparedness.

The Vector Innovation Fund is a Reserved Alternative Investment Fund (RAIF) specialising in support for technology companies able to transform global markets, notably in global healthcare, sustainability and longevity. These transformational technologies come from the nanotechnology, biotech, AI and machine learning, medical devices, therapies and digital health sectors.

Arnold Kristoff 2/2/21 Arnold Kristoff 2/2/21

Nanotech powered mass testing now the key to unlocking Covid-19 lockdowns

The World Nano Foundation and pandemic experts say regular mass use of inexpensive lateral flow rapid antigen test kits is now the way to beat back against COVID-19, its variants and future virus threats.

As vaccination gathers pace for vulnerable members of the population, the next prize is to re-open societies and get the world’s economies moving, with mass frequent testing as the key, using the mantra ‘test to suppress’, and as an early warning system to protect against new strains and future outbreaks.

These simple-to-manufacture rapid tests employ the nano colloidal gold testing method already used in diagnostics prior to the pandemic. Results have shown a thousand-fold increase in the effectiveness and accuracy of testing with this technology. The kits can produce a positive result even when there is a lower level of antigens of the virus in the sample – vital for finding asymptomatic individuals and potential ‘super-spreaders’.

In what many believe was the trial for nationwide testing to end the lockdown, the UK’s anti-COVID-19 resources were mobilised for a door-to-door delivery of lateral flow test (LFT) kits – the UK government has secured more than 400 million of these – for its test to suppress strategy as well as to address fears that the South African variant had broken out in areas of the country.

Other countries and industry groups are now adopting this technology.

Innova Medical – the world's largest manufacturer of rapid antigen test kits – has also confirmed that its COVID-19 product is effective in detecting variant strains such as the UK (Kent), South Africa, and Brazil variants, which appear more contagious than the original.

Elliot added that numerous scientific studies have shown that rapid antigen tests are an important tool for identifying infectious people quickly and equitably, even when they may not have COVID-19 symptoms, in ways not possible with slower, more expensive, centralised lab-based tests.

Innova produces more than 10 million test kits daily but aims to ramp this up to 50 million by spring and rivals are expected to follow suit.

A trial is already under way in France using a music theatre to give day pass security so that people can start attending mass events again.

World Health Organisation Special Envoy on COVID-19, David Nabarro, had already suggested this approach:

"We’ve seen it (rapid mass testing) used in many different locations, particularly for example in trying to keep aircraft free of people who’ve got COVID or looking after major events.”

Using LFTs will keep economies open, health systems safe and allow audiences to attend entertainment and sporting events, he added.

A UK Government initiative offering LFTs in workplaces started with essential health workers, the education sector, and local authorities in the UK. Private companies have also been given the option – early adopters included the Royal Mail, DVLA and Tate & Lyle Sugars.

Britain’s Health Secretary Matt Hancock said around one in three infected people do not show symptoms, so testing was vital to break the chains of transmission; workplace testing offers peace of mind to those unable to work from home during lockdown.

He added: “LFTs have already been hugely successful in finding positive cases we would not otherwise find, and I encourage employers and workers to take up this offer to help protect essential services and businesses.”

Oxford University researchers found the UK Government's most sensitive LFTs detected 83-90% of all infectious cases of COVID-19 and, with the UK investing more than £1.5bn in these test kits so far, Oxford’s Regius Professor of Medicine Sir John Bell underlined the benefit of these removing infectious people from high-risk environments: “They’ve found 25,000 cases just in healthcare, which may have prevented tens of thousands of cases of the disease.”

The World Nano Foundation (WNF) promotes healthcare technology and predicts that mass testing is central to future pandemic protection.

“Used alongside vaccines, hand-cleansing, and social distancing, these simple tests have been developed from colloidal gold nanoparticle research and are a vital component in the battle to defeat COVID-19, future variants or other viruses.

“Rapid community testing is simpler, faster, cheaper, ultimately more effective and mobilises everyone to help themselves and their relatives, friends, and colleagues – we can all play a part in keeping everyone safe.

“As West Africa reeled under the impact of Ebola (2014-16) the world watched with bated breath to see if the ‘beast’ would go global, but frequent mass rapid testing was deployed at community level multiple times over a few weeks stopping that terrible disease in its tracks.

“With the work that we do, we know that there are even more exciting technologies on the way that will be central to the world’s fight for pandemic protection and future healthcare.

“We have already seen the danger from not being on our guard against renewed viral threats. Spanish Flu struck in 1918 and ultimately killed up to 50 million people in four successive waves, the last two being most deadly because public health warnings were not adhered to.

“The UK Government’s foresight in being first to secure large stocks of rapid lateral flow antigen test supplies by Innova Medical (USA) and SureScreen Diagnostics (UK) may prove to have been a human and economic lifesaver.”

Other innovations include using similar nano technology developed by UC San Diego that turns a face mask a different colour when it detects the presence of COVID-19 in the air that you breathe, allowing everyone to self-monitor easily and simply.

This means that there will be a revolution in the healthcare industry over the next 12 months. Healthcare investment is expected to grow at a rate of nearly 50% a year towards a market set to be worth $1.333 trillion by 2027*. The acceleration highlights wide recognition that the world cannot afford the human and economic cost of another pandemic.

Image: Shutterstock - Mark Duransky